Scintillation was one of the first physical phenomena exploited for the detection of radiation and particles. Due to their great advantages in versatility, flexibility, and scalability, scintillator-based particle detectors remain widespread in fundamental nuclear and particle physics research. They are also in the toolkit of other branches of experimental physics, astronomy, and medical diagnostics. This lecture will elaborate the working principles of scintillator-based particle detectors, and explore some of their many applications. This lecture is adapted from the Detector Physics course at Fysikum.