Genetic epidemiology of complex traits

I will give examples of research at the Department of Medical Epidemiology and Biostatistics (MEB) at Karolinska Institutet, through (i) a recent GenomeWide Association Scan (GWAS) for prostate cancer, (iii) a three state illness-death frailty model for dementia and death in Swedish twins and (iii) plans for LifeGene, a Swedish Population Project on Lifestyle, Genomics and Health.

(i) Amundadottir et al. A common variant associated with prostate cancer in European and African Populations. Nature Genetics, June 2006;6:652-8.
(ii) Ripatti S, Gatz M, Pedersen NL, Palmgren J: A Three-State Frailty Model for Age at Onset of Dementia and Death in Swedish Twins. Genet Epidemiology 2003;24:139-149.